منابع مشابه
Podocyte injury can be catching.
Podocyte loss is a central mediator of glomerular sclerosis. Because podocytes are terminally differentiated cells that lack the potential to proliferate, they are particularly vulnerable to attrition in response to critical levels of cell stress, leading to detachment, necrosis, or apoptosis. Just how much podocyte loss is necessary to generate an initial sclerotic lesion and whether injury ca...
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پرستاری از بیمار مبتلا به بیماری آلزایمر چندان ساده نیست. حتی اگر از این امر که اختلال رفتاری فرد نشانه ای از بیماری اوست، آگاه باشید، اکثر مواقع نمی دانید که چگونه باید با او رفتار کنید. در این مقاله روشهای مناسبی ارائه گردیده تا خانواده بیمار بتواند با ۱۰ اختلال رفتاری شایع در بیماران مبتلا بدون احساس ناامیدی و خشم سازگاری یابند.
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In our study [4], FGF2 and FGF2-neutralizing antibody were administered to animals with PAN nephropathy. After PAN injection, recombinant FGF2 Introduction (group F), FGF2-neutralizing antibody (group M) or the same volume of physiological saline (group C) was Recent studies point to an important role for podocytes injected for 4 days via the tail vein, and the animals in the physiology and pat...
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Podocyte loss is a general mechanism of glomerular dysfunction that initiates and drives the progression of chronic kidney disease, which affects 10% of the world population. Here, we evaluate whether the regenerative response to podocyte injury influences chronic kidney disease outcome. In models of focal segmental glomerulosclerosis performed in inducible transgenic mice where podocytes are t...
متن کاملToll-like Receptor 9 Can be Activated by Endogenous Mitochondrial DNA to Induce Podocyte Apoptosis.
Toll-like receptor 9 (TLR9) senses bacterial DNA characteristic of unmethylated CpG motifs to induce innate immune response. TLR9 is de novo expressed in podocytes of some patients with glomerular diseases, but its role in podocyte injury remains undetermined. Since TLR9 activates p38 MAPK and NFkB that are known to mediate podocyte apoptosis, we hypothesized that TLR9 induces podocyte apoptosi...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2011
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2011050486